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Extreme breast hypofractionation –

preoperative external beam Radiotherapy

Phase I study:

1 x 15 Gy (n=8)

1 x 18 Gy (n=8)

1 x 21 Gy (n=16)

Followed by lumpectomy within 10 days

In low-risk patients

In prone position

Median follow-up: 23 months

Toxicity grade 1-2

Cosmetic outcome: good-excellent

Horton IJROBP 2015