Flipping Book - ATP

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Clinical evaluation: comparison of toxicity data
from different protocols
• Biologically Effective Dose
 A parameter that is independent from the fractionation
 It doesn’t express a real delivered dose
β α
β α
/
/
2
1
1
2
+
+
=
d
d
D
D
1
β α
β α
/ 0
/
1
1 +
+
= d
D
BED
2






+ ⋅ =





+ = 1
/
1
/
1
1
1
1 β α β α
d dN d D BED
3
N: fraction number
d1: fraction number
α/β: alfa-beta ratio
for the given effect