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Cost Function
prescribed dose
dose in
pixel
i
maximum
dose
in OAR
m
importance
(
)
∑
∑
−
+
>
OARs
all
m
pixels
OAR
i
OAR
OAR
m OAR
i
OAR in Pixels
D D
w
D
D
m
m
m
2
minimize
and
Minimize the energy imparted, subject to: