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Uncertainties Affect Outcomes
Variations in geometry, biology, & dosimetry.
Relative importance of variations depend on:
Anatomical site, individual patient
Institutional practices –
Peters L,
et al, J Clin. Oncol 28:2996 (2010)
Organ Motion:
Langen and Jones, IJROBP 2001
P.J. Keall, G.S. Mageras, et al.
“
The management of respiratory motion in
radiation oncology
”
, report of AAPM Task Group 76
Full issues:
Seminars Rad Onc Jan 2004, Jul 2005, 17(4) 2007
Understand objectively to control impact:
On target, with minimum variation.