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Workload and Radiotherapy Quality
TROG trial and Tyrapazamine in Head and Neck Cancers
Quality audit on Radiotherapy (JCO)
Number of
patients
Major protocol
deviation
1-4
5-9
10-19
>20
29,8
21,5
11,8
5,5
Major violation : poor coverage of
the T or N leading to a lower survival
and no impact of the drug but in
patients well treated, the drug
was active
!
LOCOREGIONAL RELAPSE
Compliance to RT
RT+DDP
RT+DDP/TPZ
Dose < 60 Gy
Dose > 60 Gy
36 %
23.8 %
42.7 %
18 %
Discussant Van Houtte P. 36.04-07