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PET: Weaknesses

Needs matching with morphological techniques

PET/CT or PET/MRI hybrid scanners

Possible matching errors in moving structures

Size of hot areas dependent on windowing

Does not show real tumour extension

FDG-PET not necessarily tumour-specific

Uptake in inflammatory conditions

Some tumours need specific tracers

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Ga-DOTATOC for neuroendocrine tumours

PSMA ligand for prostate cancer