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RANO* Response criteria in CNS
tumors
Criterion
CR
PR
SD
PD
T1 Gd-enhancing
disease
None
≥50% decrease
<50% decrease but
<25% increase
≥25% incrase
T2/FLAIR lesion Stable or
decreased
Stable or
decreased
Stable or
decreased
Increased
New lesion
None
None
None
Present
Corticosteroids
needed
None
Stable or less
Stable or less
N/A or more
Clinical status
Stable or improved Stable or improved Stable or improved Deteriorated
Requirement for
response
All
All
All
Any
Wen PN et al. JCO 28:1963-1972 (2010)
* RANO = Response assessment in neuro-oncology