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How to set the Clinical tolerance limit (
TL
)?
Clinical tolerance limits or specifications should be based on
clinical experience.
Clinical experience can be summarized through statistical
analysis of the outcome of a particular treatment for a particular
tumor disease.
Examples:
Local tumor control as a function of dose.
Fraction of survivors after five years as a function of dose.
At the same time, normal tissue complications must be taken
into account.
T.
From JörgenOlofsson (Dose Modeling and dose verification ESTRO COURSE)