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Orlandi RR, Smith TL, Marple BF, et al. Update on evidence-based reviews with
recommendations in adult chronic rhinosinusitis.
Int Forum Allergy Rhinol
. 2014; 4
Suppl 1: S1-S15. EBM level NA...............................................................................32-46
Summary
: Orlandi et al present expert panel guidelines based on a systematic literature review.
This review synthesizes the findings of eight evidence-based reviews with recommendations
regarding chronic rhinosinusitis published in the
International Forum of Allergy and Rhinology
between 2011 and 2014.
c.
Subtypes of CRS
Han JK. Subclassification of chronic rhinosinusitis.
Laryngoscope
. 2013; 123 Suppl
2:S15-S27. EBM level 2b...........................................................................................47-59
Summary
: This article presents a working classification of the common clinical subtypes of
chronic rhinosinusitis (CRS). The author presents a clinical and laboratory work-up to subtype
CRS.
2.
Pathophysiology
a.
Pathophysiology of CRS
i.
Role of innate and adaptive immunity
Adappa ND, Zhang Z, Palmer JN, et al. The bitter taste receptor T2R38 is an
independent risk factor for chronic rhinosinusitis requiring sinus surgery.
Int
Forum Allergy Rhinol
. 2014; 4(1):3-7. EBM level NA..................................60-64
Summary
: Adappa et al studied tissue of chronic rhinosinusitis (CRS) patients undergoing
primary functional endoscopic sinus surgery. The tissue was studied for genotype
TAS2R38
. The
TAS2R38
genotype was found to be an independent risk factor for CRS
patients who failed medical therapy and required surgical intervention.
Hox V, Maes T, Huvenne W, et al. A chest physician's guide to mechanisms of
sinonasal disease.
Thorax
. 2015; 70(4):353-358. EBM level 4.....................65-70
Summary
: This review focuses on both endogenous predisposing factors and exogenous
triggers that may contribute to chronic upper airway disease and can also impact lower
airway disease.
Oakley GM, Curtin K, Orb Q, et al. Familial risk of chronic rhinosinusitis with
and without nasal polyposis: genetics or environment.
Int Forum Allergy Rhinol
.
2015; 5(4):276-282. EBM level 3....................................................................71-77
Summary
: This study used an extensive genealogical database from the state of Utah and
linked medical records to study the risk of chronic rhinosinusitis with nasal polyps
(CRSwNP) and without polyps (CRSsNP) in relatives and spouses of adult probands
(1638 CRSwNP and 24,200 CRSsNP patients). These were compared to random
population controls matched 5:1 on gender and birth year.
ii.
Microbiome
b.
Pathophysiology of tumors
Tajudeen BA, Arshi A, Suh JD, et al. Importance of tumor grade in
esthesioneuroblastoma survival: a population-based analysis.
JAMA Otolaryngol Head
Neck Surg
. 2014; 140(12):1124-1129. EBM level NA.............................................78-83
Summary
: This article is a population database review presenting tumor-related outcomes and the
impact of tumor grade/adjuvant radiation therapy on outcomes.