1988-1989 / 2239
Invariant and Variant Dose Distributions
Cho et al MP 2002
• Invariant (main effect on DVH):
– Negligible dosimetric effect from contour or
tissue inhomogeneity effects as function of
displacement
• Variant (secondary effect):
– Due to tissue inhomogeneity and contour
effects as well
• Conclude:
Utrecht 2016
– Differences in relative volume and relative
dose depending on displacement
– Variant effects of contour changes,
inhomogeneities and set up are negligible on
EUD
Note: Worst case!