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Including uncertainties
• Current practice not include patient specific uncertainty
analysis (Setup, intra/inter fraction motion, structure
delineation
• Probabilistic TP (PTP) does away with PTV
• Dose to an element of tissue considered as a random variable
Utrecht 2016
– Organs and tumour moving through dose cloud
• Need to define probability density function of anticipated
uncertainties
– Define dose coverage to CTV not PTV
– Use the multiple image data sets acquired during
treatment initial fractions