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Including uncertainties

• Current practice not include patient specific uncertainty

analysis (Setup, intra/inter fraction motion, structure

delineation

• Probabilistic TP (PTP) does away with PTV

• Dose to an element of tissue considered as a random variable

Utrecht 2016

– Organs and tumour moving through dose cloud

• Need to define probability density function of anticipated

uncertainties

– Define dose coverage to CTV not PTV

– Use the multiple image data sets acquired during

treatment initial fractions