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Analytical Challenges
•
Number of potential synthetic PDE5 inhibitors:
th 100 k
l
–
more an
nown ana ogs
–
more than 50 analogs reported as adulterants
•
Availability of reference standards
•
Inventiveness of adulterators:
–
exotic analogs
–
mixtures of analogs
–
embedding of adulterants into capsule walls
•
Complex and variable dietary supplement matrices