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EGFR
• Growth factor receptor
erbB
encodes the EGFR
receptor
• oncogenic mutations generate
EGFR that is activated even in
the absence of EGF
• amplification of
erbB
gene(s)
increases membrane
expression of EGFR
Over-activity of RAS - MAPK pathway induces over-expression of genes
promoting proliferation and the malignant phenotype