376 / 1266
commonest mutation is deletion of exons 2 - 7:
• mutant protein (EGFRvIII) cannot bind ligand but is
constitutively activated
• common in high grade gliomas (25-30%)
|
|
376 / 1266
commonest mutation is deletion of exons 2 - 7:
• mutant protein (EGFRvIII) cannot bind ligand but is
constitutively activated
• common in high grade gliomas (25-30%)