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WHAT HAVE WE LEARNED FROM CLINICAL TRIALS :
EARLY DECLINE AFTER WBRT FOR BRAIN METASTASIS
• Two phase III trials in patients with 1-3 brain metastases
comparing SRS + WBRT with SRS alone.
• A significant decline in learning and memory function at 4 months
in patients receiving WBRT (
Chang et al, Lancet Oncol 2009
).
• A significant decline at 3 months in immediate recall, delayed recall
and verbal fluency (
Brown et al 2015, Irradiance trial, ASCO 2015
).
• Unknown whether this early decline is associated with long-term
and/or permanent decline