418 / 1266
NEW APPROACHES TO MINIMIZE
COGNITIVE DECLINE FOLLOWING WBRT
(“GENTLER WBRT”)
• Use of “protective” drugs (memantine) (RTOG 0614)
• Hippocampus avoidance with intensity modulated radiotherapy
(RTOG 0933)
• Anti-inflammatory compounds
• Identification of subgroups of patients at higher risk of developing
cognitive deficits
Gondi and Mehta, Curr Opin Neurol 2010;
Steeg et al, Nat Rev Cancer 2011