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Hippocampal Injury from Cranial RT
• Preclinical evidence
– 97% reduction in
hippocampal
neurogenesis 2
months after cranial
RT
– Up-regulation of
microglial
differentiation and
activation
Blue:
GCL,
Green:
SGZ
Monje et al, Nat Med 2002; Gondi et al, JCO 2010.
Black:
Cranial RT
White:
Control