493 / 1266
‘Stupp’ regime
•
radiotherapy to enhancing tumour or resection cavity plus 2-3 cm
margin
•
daily temozolomide 75 mg/m
2
during radiotherapy
•
standard radiotherapy dose (60 Gy 30#)
•
6 cycles of adjuvant temozolomide (5/28 days)
–
1st cycle 150 mg/m
2
–
escalate to 200 mg/m
2
if tolerated
–
about 50% of patients completed 6 cycles