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48 year old patient with MGMT unmethylated GBM, >90%
resection, PS=1 post-op. Completes RT-TMZ. She attends for 1
st
cycle adjuvant TMZ; PS now 2: fatigue, poor short term memory.
Your recommendation is:
A. Commence adjuvant TMZ as protocol
B. Defer adjuvant TMZ until PS = 1 or better
C. Commence adjuvant TMZ but reconsider after
cycle 1
D. Decision to proceed with adjuvant TMZ depends
on result of MRI scan after RT/TMZ
E. Advise patient no benefit from adjuvant TMZ