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EP and chemotherapy
•
Direct evaluation of the response of EP to several chemotherapy
agents has
failed
to demonstrate significant chemosensitivity
•
However, given the concern of radiation-related neurotoxicity in
(very) young children,
several trials of postoperative
chemotherapy
have been undertaken
•
Response rate to single agents is
11%
, with <
5% complete
responses
,
CDDP
being the most active agent in phase II studies
03/01/13