585 / 1266
Design of protocol
Option A :
radiotherapy of craniospinal axis : 24 Gy (5 x 1.6 Gy / week)
followed by RT to tumour site : 16 Gy (5 x 1.6 Gy / week)
Total tumour dose : 40 Gy
Option B :
2 courses Carbo PEI
(600mg/m2 d1 -- VP16 150mg/m2 d1-3/22-24 – Ifosfam. 1800mg/m2 d22-26)
followed by RT to tumour site : 40 Gy (5 x 1.6 Gy / week)
SIOP CNS GCT 96 / germinoma