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Initial studies utilizing hyperfractionated radiation
therapy with total doses up to 72 Gy (1 Gy twice day)
suggested a modest improvement in survival of
children with brainstem gliomas compared to radiation
alone, and compared to radiation with neoadjuvant or
adjuvant chemotherapy
Packer et al. 1993
However, subsequent trials using radiation doses up to 78
Gy did not confirm this finding
Packer et al. 1994
Radiotherapy