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Children’s Cancer Group 945

131 patients with a diagnosis of AA or GBM

Surgery biopsy (<10% resection)

Partial resection (10-50%)

Subtotal resection (50-90%)

Radical (90%)

PFS at 5 years rate of 35% in radical resection compared with 17% in

subtotal resection (p= 0.006)

AAs

PFS at 5 years 44% in radical vs. 22% in subtotal (p= 0.055)

GMB

PFS at 5 years rate of 26% in radical vs. 4% in subtotal (p= 0.046)

Wisoff et al. J Neurosurg 1998

Surgery