736 / 1266
Rationale for chx. before RT
Open blood brain barrier (surgery)
lesser toxicity of agents, greater selection
of protocols, reduction of tumour burden
Rationale for chx. during RT
Radiosensitization
Rationale for chx. after RT
Elimination of persistent tumour cells
Maintenance approach to prevent early relapse
Chemotherapy in childhood HGG
Rationale