957 / 1266
Baseline Patient Characteristics
Dose cohort
3 mg/kg
(n = 3)
3.75 mg/kg
(n = 10)
4.50 mg/kg
(n = 8)
5.25 mg/kg
(n = 6)
Total
(N = 27)
Mean age (years)
Range
8.7
4
−
14
11.6
3
−
17
6.5
1
−
17
7.7
3
−
12
8.9
1
−
17
Sex
Female
Male
1
2
5
5
3
5
3
3
12
15
Tumor type
3 HGG
5 HGG; 3
LGG
1 LCH; 1 PTC
6 LGG; 1 LCH
1 NB
6 LGG
8 HGG; 15 LGG;
2 LCH; 1 PTC;
1 NB
- HGG
histology
2 AA; 1 AG 2 GBM; 1
AGG
1 AA; 1 APXA
- LGG
histology
1 JPA; 1GG;
1 PMA
4 JPA; 2 GG
1 PXA; 1 JPA;
1 GG; 3 LGG
AA
, anaplastic astrocytoma;
AG
, anaplastic glioma;
AGG
, anaplastic ganglioglioma;
APXA
, anaplastic pleomorphic xanthoastrocytoma ;
GBM
, gliobastoma multiforme;
GG
, ganglioglioma;
HGG
, high grade glioma;
JPA
, juvenile pilocytic astrocytoma;
LCH
, Langerhans cell
histiocytosis;
LGG
, low grade glioma;
NB
, neuroblastoma;
PMA
, pilomyxoid astrocytoma;
PTC
, papillary thyroid carcinoma;
PXA
,
pleomorphic xanthoastrocytoma.
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