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BRAFV600 Mutations in Pediatric Tumors
•
~60% papillary thyroid carcinoma
1
•
~60% Langerhans cell histiocytosis
2
•
~50% melanoma
3,4
•
~10% Low grade gliomas
–
~10% fibrillary astrocytoma, pilocytic astrocytoma
5
–
~60% pleomorphic xanthoastrocytoma
6
–
~60% gangliogliomas
7
•
~10% malignant astrocytomas
8
1
. Henke LE, et al.
Pediatr Blood Cancer
2014;61:1168–1172;.
2
Badalian-Very G, et al.
Blood
2010;116:1919–1923;
3
.Daniotti M, et al.
J Invest Dermatol
2009;129: 1759–1768;
4
. Lu C, et
al.
J Invest Dermatol
2015;135:816–823;
5
. Bergthold G et al.
Neuro Oncol
2015;pii:nov045;
6
. Dias-Santagata D, et al.
PLoS One
2011; 6:e17948;
7
. MacConaill LE, et al.
PLoS One
2009;
4:e7887;
8
. Nicolaides TP, et al.
Clin Cancer Res
2011;17:7595-7604.
106