worth mentioning that neither technetium nor gallium scans
were routinely used for diagnosis or monitoring of disease;
thus, it is possible that some patients with clinical and radio-
graphic evidence of resolution may have in fact had ongoing
infections. Finally, because many of our patients travel long
distances for care at our center, they often elect to follow up
with their local otolaryngologists after the completion of
treatment and apparent resolution of their infections. This
precluded us from following outcomes for the majority of
the patients in our study beyond 1 month after the comple-
tion of antibiotic therapy.
Conclusions
Our study underscores the increasing frequency of non-
Pseudomonas
causes of MOE and specifically highlights
that MRSA is an increasingly important organism leading to
MOE. A high index of suspicion for atypical organisms,
such as MRSA, should be maintained in patients with signs
and symptoms of MOE who do not have diabetes.
Author Contributions
Candace E. Hobson
, Data acquisition and analysis, interpretation
of data, drafting of manuscript, final approval;
Jennifer D. Moy
,
data acquisition, critical revision of manuscript, final approval;
Karin E. Byers
, Study conception and design, critical revision of
manuscript, final approval;
Yael Raz
, study conception and design,
critical revision of manuscript, final approval;
Barry E. Hirsch
,
study conception and design, critical revision of manuscript, final
approval;
Andrew A. McCall
, study conception and design, analy-
sis and interpretation of data, drafting and critical revision of
manuscript, final approval.
Disclosures
Competing interests:
None.
Sponsorships:
None.
Funding source:
None.
References
1. Meltzer PE, Keleman G. Pyocyaneous osteomyelitis of the tem-
poral bone, mandible and zygoma.
Laryngoscope
. 1959;69:1300.
2. Chandler JR. Malignant external otitis.
Laryngoscope
. 1968;
78:1257-1294.
3. Rubin J, Yu VL. Malignant external otitis: insights into patho-
genesis, clinical manifestations, diagnosis, and therapy.
Am J
Med
. 1988;85:391-398.
4. Bayardelle P, Jolivet-Granger M, Larochelle D. Staphylococcal
malignant external otitis.
Can Med Assoc J
. 1982;126:155-156.
5. Ali T, Meade K, Anari S, ElBadawey MR, Zammit-Maempel
I. Malignant otitis externa: case series.
J Laryngol Otol
. 2010;
124:846-851.
6. Soudry E, Hamzany Y, Preis M, Joshua B, Hadar T, Nageris
BI. Malignant external otitis: analysis of severe cases.
Otolaryngol Head Neck Surg
. 2011;144:758-762.
7. Chen CN, Chen YS, Yeh TH, Hsu CJ, Tseng FY. Outcomes of
malignant external otitis: survival vs mortality.
Acta Otolaryngol
.
2010;130:89-94.
8. Yu LH, Shu CH, Tu TY, Shiao AS, Lien CF. Malignant otitis
externa.
Chin Med J
. 1999;62:362-368.
9. Moran GJ, Krishnadasan A, Gorwitz RJ, et al. Methicillin-
resistant S. aureus infections among patients in the emergency
department.
N Engl J Med
. 2006;355:666-674.
10. Cohen D, Friedman P. The diagnostic criteria of malignant
external otitis.
J Laryngol Otol
. 1987;101:216-221.
11. Mehrotra P, Elbadawey MR, Zammit-Maempel I. Spectrum of
radiological appearances of necrotising external otitis: a pictor-
ial review.
J Laryngol Otol
. 2011;125:1109-1115.
12. Joshua BZ, Sulkes J, Raveh E, Bishara J, Nageris BI.
Predicting outcome of malignant external otitis.
Otol Neurotol
.
2008;29:339-343.
13. Jacobsen LM, Antonelli PJ. Errors in the diagnosis and man-
agement of necrotizing otitis externa.
Otolaryngol Head Neck
Surg
. 2010;143:506-509.
14. Bernstein JM, Holland NJ, Porter GC, Maw AR. Resistance of
Pseudomonas to ciprofloxacin: implications for the treatment of
malignant otitis externa.
J Laryngol Otol
.
2007;121:118-123
.
15. Berenholz L, Katzenell U, Harell M. Evolving resistant pseudo-
monas to ciprofloxacin in malignant otitis externa.
Laryngoscope
.
2002;112:1619-1622.
16. Elamurugan TP, Jagdish S, Kate V, Chandra Parija S. Role of
bone biopsy specimen culture in the management of diabetic
foot osteomyelitis.
Int J Surg
. 2011;9:214-216.
Otolaryngology–Head and Neck Surgery 151(1)
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