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Margins for small leasions hypo fractionated

Adding up some/al the errors:

Delineation uncertainty

2 mm

Residual set up error after imaging (2D or 3D)

bone registration

0.5 mm

soft tissue changes

0.6 mm

Intrafraction motion

0.6 mm

PTV margin =

2.5

Σ

+

0.7

σ

1mm margin/ 0mm margin??

Literature show excellent local controle!