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DW-MRI to inform tumour boost
Mean conventional GTV was 31.0 cm
3
(range 6.7-78.7cm
3
).
Mean DW-MRI GTV was 16.1cm
3
(range
0-35.3cm
3
).
There was significant reduction in GTV
using DW-MRI (p=0.002).
Acquiring DW-MRI for radiotherapy
planning may complement target
volume delineation and inform non-
uniform dose delivery to biological
sub-volumes for bladder radiotherapy
dose escalation trials.
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Tumour voulme (cm3)
Patient
Individual change in tumour bed volume
Anatomically defined tumour bed
DW-MRI defined tumour bed
Hafeez et al., Characterisation of tumour boost with diffusion weighted MRI (DW-MRI) to inform biological target volume for radical
radiotherapy in muscle invasive bladder cancer (MIBC) NCRI 2015.