Microsoft Word - Scientific Program IGRT 2016 Madrid V3

RTOG 0617 – Dose escalation

60 Gy

74 Gy

25.1%

34.4%

Local failure rate at 18 months post-treatment:

03/01/13

Does this make sense?

Reasons?

Bradley et al.,

Lancet Oncology

2015

Minimum margin was smaller in the high-dose group (mean 4·5 mm [2·9] in the

standard-dose group

vs 3·9 mm [3·0] in the high-dose group; p=0·0047)