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GI

GU

MDACC

70Gy

78Gy

13%(10-y)

26% G2+ (10-y)

8% (10-y)

13% (10-y)

MRC RT 01

64Gy

74Gy

24%(5-y)

33% (5-y)

8% (5-y)

11% (5-y)

CVKO 9610

68Gy

78Gy

27%(5-y)

32% (5-y)

41% (5-y)

39% (5-y)

PROG

70.2Gy

79.2CGE

8% (5-y)

10% (5-y)

18% (5-y)

20% (5-y)

Dose escalation in 3D-CRT and late toxicity