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Uncertainty management: Probabilistic

biological IMRT planning without margin

CTV

Inverse

optimization

Objective functions

with simulated errors

TCP

,

NTCP

Dose

distribution

Maximum

TCP

for given

OAR

NTCP

OAR

Σ

,

σ

no PTV margin!

Witte et al, IJROBP 2007

Bohoslavsky et al, IJROBP 2013