AOAC SPIFAN ERP Meeting Book (3-16-16)

Fonterra Co-operative Group

Page 3

Table of Contents

Summary....................................................................................................................................................... 2

Table of Contents.......................................................................................................................................... 3

Introduction ................................................................................................................................................... 4

Method .......................................................................................................................................................... 4

Principle ........................................................................................................................................................ 4

Validation ...................................................................................................................................................... 4

Samples ........................................................................................................................................................ 4

Linearity ........................................................................................................................................................ 5

Precision ....................................................................................................................................................... 8

Limits of Detection and Quantitation............................................................................................................ 10

Recovery..................................................................................................................................................... 11

Bias Against CRM ....................................................................................................................................... 12

Bias Against Reference Method .................................................................................................................. 14

Chromatography ......................................................................................................................................... 14

Mass Spectrometry ..................................................................................................................................... 15

Pre-Vitamin D.............................................................................................................................................. 16

Acknowledgements ..................................................................................................................................... 17

References.................................................................................................................................................. 17

Appendix A: Data

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Linearity ....................................................................................................................... 18

Appendix B: Data

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Precision ...................................................................................................................... 20

Appendix C: Data

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Limits of Detection and Quantitation............................................................................. 23

Appendix D: Data

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Recovery...................................................................................................................... 24

Appendix E: Data

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Bias Against CRM ........................................................................................................ 27

Appendix F: Data

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Bias Against Reference Method ................................................................................... 28

Appendix G: AOAC SMPR 2011.004 .......................................................................................................... 30

VitD-18 (February 2016)

FOR ERP USE ONLY

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