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M=2.5*√((

1mm

)

2

+(

1.5mm

)

2

+(

0.4mm

)

2

)+0.73*√((

1.5mm

)

2

+(

0.5mm

)

2

+(

1mm

)

2

+(4.05mm)

2

)-0.73*4.05mm

Penumbra:

σ

p

=4.05mm

β=0.73

(for 80% isodose)

Prediction error tolerance level of 3 mm

R=3 mm

3 mm

rebuild CM

1.5 mm

σ

= 1.5 mm (dose blurring)

Σ= 1.5 mm (shift)

Gimbals systematic

error

Mechanical tracking

errors

-surrogate vs TV relative rotation in

relative ITV

+

marker-TV surrogate

uncertainty

Σ=CT-slice/2=1 mm

Σ= 0.4 mm

σ

= 0.5 mm

3 mm

CTV-PTV margin calculation

Based on Van Herk et al. 2000

Correlation model

Fit errors (

σ

= 1 mm)