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Monte Carlo sim.

of the integration of the 4D MC dose calculation process with beamlet-phase correlation in the overall clinical workflow. Bottom part corresponds to the

cific to this study. The top-left part corresponds to the conventional clinical process. The top-right part corresponds to the additional PET-based contouring

.

D

P

3

D

denotes the planned dose map computed with TomoPen,

D

IS

4

D

ð

i

Þ

and

D

NI

4

D

ð

i

Þ

the dose computed at phase

i

with interplay effect simulated or not,

(i)

the deformation between the phase

i

and the 3D CT. Finally,

D

IS

3

D

and

D

NI

3

D

denote the computed dose including interplay effect or not, respectively.

E. Sterpin et al. / Radiotherapy and Oncology 104 (2012) 173–180

175

Sterpin et al.,

Radiotherap and Oncology 104 (2012) 173–180

Tech.

Δ

(Dp,ptv - Dc,ctv)

Interplay

Δ

(Dp,ptv - Dc,ctv)

Mov. only

4DCT-SIB

0.45%

(-1.3,2.7)

0.47%

(-1.4,2.7)

4D-PET SIB -0.34%

(-1.2, 2.6)

-0.29%

(-2.4,2.1)

SBRT 3x18Gy

1.19%

(-1.5,2.8)

1%

(-2,2.8)