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Name I Folie 1 I Datum

Dominant intraprostatic lesion

= cancer-validated areas within the prostate as target for dose escalation

1

Pucar D, et al. IJROBP 2007; 69: 62-69

2

Cellini N, et al. IJROBP 2002; 53: 595–599

3

Coen JJ, et al. JCO 2002; 20: 3199-3205

4

Jacob R, et al. Cancer 2004; 100: 538-543

Clinically significant prostate cancer local recurrence after

radiation therapy occurs at the site of primary tumor

1,2

Relationship: local control - distant metastasis - survival

3,4