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Shaikh et al. :
“Our analysis finds that helical
tomotherapy treatments are generally superior to SMLC and DMLC
treatment plans in this aspect due to the relatively
rapid dose accumulation
seen by a given target
volume element.”
“… Newer rotational delivery techniques such as
VMAT
, which are capable of total treatment delivery
times shorter than any of the techniques studied here, should be expected to result in
similar biological
effects to those from helical tomotherapy
as presented here.”
“If the
relationships between treatment time and biological effectiveness
were accurately known for
clinical situations, one could modify the prescription dose to compensate. Unfortunately, these
relationships are not completely understood and depend on factors that are not accurately known
(i.e., α /
β ratios and repair half-times, etc.)