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ESTRO IMRT course 2015
IMRT optimization: algorithms&cost functions
Brussels October 5th, 2015
-64-
Clinical relevance of the serial cost function
M. Söhn et al. 2007 (IJROBP 67(4))
Quantec-Report: J. M. Michalski et al. 2010 (IJROBP 76(3))
1 ,
1
1
≥
=
∑
=
k D
N
F
N
i
k
i
serial
directly related to…
k
N
i
k
i
serial
D
N
EUD
∑
=
=
1
1
k = ~13.5
EUD
serial
[Gy]
For rectal complications (grade>=2 bleeding)
strong clinical evidence, that NTCP is clearly
related to rectal EUD!