67 / 1544
Conclusions:
The use of image-guided and intensity-modulated radiotherapy
(IG-IMRT) results in very low rates of acute grade 3 toxicity
in both arms (6% vs 4%)
IMRT improves significantly the tolerance of preoperative RT
for rectal cancer, especially radiation enteritis
Higher pCR rates are observed in the chemo-RT arm (24% vs 14%
in the RT-SIB arm), no differences in major tumoral
downstaging
Difference in SUVmax reduction -2.9% in favor of chemoRT (95%
CI, -10.1% to 4.3%, p = 0.06) => RT-SIB marginally failed to
prove non-inferiority to chemoRT
compared to chemoRT for T3-4 rectal cancer:
a multicentric randomized trial
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