Ductal Carcinoma
In Situ
351
FIG. 11.21.
DCIS, cribriform.
A:
Minimal microlumen formation, some with calcifications. Nuclei are
of low grade.
B:
Relatively round microlumina in the distended duct with low-to intermediate-grade
nuclei.
C:
Central and peripheral microlumina with central necrosis and calcifications.
D:
Microlu-
mina with irregular contours. There is central necrosis with calcification.
A
B
C
D
FIG. 11.22.
DCIS, cribriform.
A:
Peripheral microlumina, some of which are slit shaped, and a prom-
inent central lumen with degenerating cells and calcification.
B:
Magnified view showing degen-
erating tumor cells in the lumen.
C:
Another duct from the same specimen with a conventional
cribriform structure.
D:
DCIS with conventional cribriform structure. The duct is filled with histio-
cytes and calcifications.
