91 / 266
64
M
O
N
D
A
Y
1002-Plat
4:30 pm
MECHANISM OF AMPA RECEPTOR GATING RE-SHAPED BY AUXILIARY
PROTEINS.
George B. Dawe
, Derek Bowie
1003-Plat
4:45 pm
SENSING ALLOSTERIC MODULATOR BINDING TO AMPA RECEPTORS AT
THE GLUTAMATE-BINDING SITE.
Christopher P. Ptak
, Ahmed H. Ahmed,
Robert E. Oswald
1004-Plat
5:00 pm
ACID SENSING ION CHANNELS ARE UNIQUELY TUNED TO FOLLOW HIGH
FREQUENCY ‘SYNAPTIC’ STIMULI.
David M. MacLean
, Vasanthi
Jayaraman
1005-Plat
5:15 pm
HUMAN α1 GLYCINE RECEPTOR ALLOSTERY AS IDENTIFIED BY STATE-
DEPENDENT CROSSLINKING STUDIES.
Michael Cascio
, Rathna J.
Veeramachaneni, Jeffry Madura
1006-Plat
5:30 pm
CRYSTAL STRUCTURE OF HUMAN GLYCINE RECEPTOR-α3 BOUND TO
ANTAGONIST STRYCHNINE.
Xin Huang
1007-Plat
5:45 pm
MOLECULAR DETERMINANTS OF PARTIAL AGONIST AFFINITY IN ADULT
NEUROMUSCULAR ACETYLCHOLINE RECEPTORS.
Iva Bruhova
, Anthony
Auerbach
Platform
Protein-Small Molecule Interactions
4:00 pm - 6:00 pm, Room 501ABC
Co-Chairs
Alex Dickson, Michigan State University
Giulia Palermo, École Polytechnique Fédérale de Lausanne, Switzerland
1008-Plat
4:00 pm
2-DEOXY-ATP ENHANCES MULTIPLE KINETIC PARAMETERS TO IMPROVE
CARDIAC FUNCTION.
Ivan B. Tomasic
, Marcus Henze, Ferdinand
Evangelista, Anu R. Anto, Hector Rodriguez, Sadie R. Bartholomew
1009-Plat
4:15 pm
EXAMINATION OF CLPB QUATERNARY STRUCTURE AND LINKAGE TO
NUCLEOTIDE BINDING.
JiaBei Lin
, Aaron L. Lucius
1010-Plat
4:30 pm
THUMB SITE 2 INHIBITORS OF HEPATITIS C VIRAL RNA-DEPENDENT RNA
POLYMERASE ALLOSTERICALLY BLOCK THE TRANSITION FROM INITIATION
TO ELONGATION.
Jiawen Li
, Daniel Deredge, Patrick L. Wintrode,
Kenneth A. Johnson
1011-Plat
4:45 pm
MOLECULAR SIMULATIONS INTEGRATED WITH EXPERIMENTS UNRAVEL
THE KEY FACTORS OF LIPID SELECTION IN FATTY ACID AMIDE HYDROLASE
AND SUGGEST A GENERAL MECHANISM OF LIPID-PROCESSING IN THE
PARENT ENZYMES.
Giulia Palermo
, Inga Bauer, Pablo Campomanes,
Andrea Cavalli, Andrea Armirotti, Stefania Girotto, Marco De Vivo, Ursula
Rothlisberger
1012-Plat
5:00 pm
CURCUMIN-LIKE COMPOUNDS DESIGNED TO MODIFY AMYLOID BETA
PEPTIDE AGGREGATION PATTERN.
Maria Grazia Ortore
, Antonella Bat-
tisti, Ranieri Bizzarri, Donatella Bulone, Claudio Ferrero, Francesco Ghetti,
Valentina Giacalone, Antonino Lauria, Maria Rosalia Mangione, Antonella
Marino Gammazza, Caterina Ricci, Antonella Sgarbossa, Francesco
Spinozzi, Silvia Vilasi, Antonio Palumbo Piccionello
1013-Plat
5:15 pm
IN SILICO STUDY ON THE LIGAND-BINDING AND ACTIVATION MECHA-
NISMS OF THE HUMAN DOPAMINE D3 RECEPTOR.
Wei-Hsiang Weng
,
Hao-Jen Hsu
1014-Plat
5:30 pm
MIMICKING PROTEIN FUNCTIONS WITH ENTROPICALLY CONSTRAINED
PEPTIDES.
Blake Farrow
, Andrew G. Wang, David N. Bunck, James R.
Heath
1015-Plat
5:45 pm
LIGAND RESIDENCE TIMES AND EXIT PATHWAYS OBTAINED IN SILICO
WITHOUT BIASING FORCES.
Alex Dickson
Platform
Protein-Lipid Interactions I
4:00 pm - 6:00 pm, Room 511ABC
Co-Chairs
Oliver Soubias, NIH
Stephanie Tristram-Nagle, Carnegie Mellon University
1016-Plat
4:00 pm
PENETRATION OF HIV-1 TAT47-57 INTO PC/PE BILAYERS ASSESSED BY MD
SIMULATION AND X-RAY SCATTERING. Chris Neale, Kun Huang, Angel E.
Garcia,
Stephanie Tristram-Nagle
1017-Plat
4:15 pm
INVESTIGATING THE INTERACTIONS OF PERIPHERAL MEMBRANE PRO-
TEINS WITH MODEL MEMBRANES USING HIGH THROUGHPUT MOLECU-
LAR DYNAMICS SIMULATIONS.
Antreas C. Kalli
, Eiji Yamamoto, Fiona B.
Naughton, Mark S.P. Sansom
1018-Plat
4:30 pm
ELUCIDATING THE MECHANISM FOR STEROL REGULATION OF CHLORIDE
INTRACELLULAR ION CHANNEL PROTEIN INTERACTIONS WITH LIPID
MEMBRANES.
Khondker R. Hossain
, Heba Al Khamici, Stephen A. Holt,
Stella M. Valenzuela
1019-Plat
4:45 pm
TRANSIENT EFFECT OF CALCIUM INFLUX ON PIP2 CLUSTERS IN THE IN-
NER PLASMA MEMBRANE LEAFLET OF INTACT CELLS.
Weixiang Jin
, Arnd
Pralle
1020-Plat
5:00 pm
ELUCIDATING GPCR FUNCTIONAL DEPENDENCE ON PLASMA MEMBRANE
COMPOSITION USING GIANT UNILAMELLAR PROTEIN-VESICLES.
Mary
Gertrude L. Gutierrez
, Kylee Mansfield, Noah Malmstadt
1021-Plat
5:15 pm
CONTROLLING GPCR RHODOPSIN FUNCTION BY SMALL, PHYSIOLOGI-
CALLY RELEVANT CHANGES IN BILAYER HYDROPHOBIC THICKNESS.
Olivier Soubias
, Alexander J. Sodt, Walter E. Teague, Kirk G. Hines, Klaus
Gawrisch
1022-Plat
5:30 pm
CHARACTERIZATION OF CEACAM1 AND LIPID RAFT NANOCLUSTERING,
ASSOCIATION AND STRUCTURE BY DSTORM AND HOMO-FRET IMAGING.
Amine Driouchi
, Maximilano Giuliani, Scott Gray-Owen, Christopher M.
Yip
1023-Plat
5:45 pm
STRUCTURAL DETERMINANTS OF RAFT PARTITIONING FOR SINGLE-PASS
TRANSMEMBRANE PROTEINS.
Joseph H. Lorent
, Barbara B. Diaz-Rohrer,
Kandice R. Levental, Ilya Levental