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Assumptions/simplifications in derivation
of M
PTV,i
= 2.5Σ
i
+0.7σ
i
:
- large number of fractions
- spherical tumor
- ideal conformality: 95% isodose is a sperical surface coinciding with the
PTV surface (ICRU-50: 100% of PTV should get dose ≥ 95%)
- only translational set-up errors, i.e. no intra-fraction motion, no tumor
rotations, no deformations (derived margin often has to be considered
as lower limit)