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Assumptions/simplifications in derivation

of M

PTV,i

= 2.5Σ

i

+0.7σ

i

:

- large number of fractions

- spherical tumor

- ideal conformality: 95% isodose is a sperical surface coinciding with the

PTV surface (ICRU-50: 100% of PTV should get dose ≥ 95%)

- only translational set-up errors, i.e. no intra-fraction motion, no tumor

rotations, no deformations (derived margin often has to be considered

as lower limit)