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Impact of random motion on tumor dose:
tumor cells may ‘see’ high dose in some fractions, low dose in others
effect most prominent for cells at the tumor edge
effectively, tumor experiences a blurred dose distribution, different
from planning
Add random errors
M
PTV
= 2.5Σ + 0.7σ
G
For an infinite number of fractions:
Blurred dose
Planned (static) dose