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Linear Quadratic Model of cell survival
• Second order polynomial with a
zero constant term so SF = 1 at
zero dose
• Models in vivo and in vitro
responses well
• α – probability of damage due to
single track event
• β – probability of damage due to
two independent track events
• Key features of graph
•
Continuously bending
•
Semi-log plot
•
α/β (Gy) is dose where linear
component to damage (αD) =
quadratic component (βD
2
)