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The NTCP volume effect model (LKB model)
• Sigmoidal dose response curve,
parameters include
•
Slope parameter, m
•
TD50 parameter (tolerance dose
for 50% response)
•
Volume parameter, n where n=0
no volume effect to n=1 large
volume effect
•
Reference volume of whole organ
• Equation which reduces dose
heterogeneity to a single
number