2830-2831 / 3107
Late effects of therapeutic radiation
•
Occur > 90 days after
treatment completion
• Cause more complex: Due to
cell loss, vascular effects and
premature differentiation
• Generally irreversible
• Fibrosis and organ atrophy
often seen which continues
to progress over years
• Occur in all tissues but most
commonly seen in lung,
kidney, heart, liver, CNS and
skin