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Comparison of different scoring systems: Breathlessness
Persistent cough, SOB
at rest
SOB with minimal
exertion; limiting ADL
2
Mild dry cough, SOB
on exertion
SOB with moderate
exertion
1
None
None
0
RTOG
NCI CTCAE v4.0
GRADE
Death
Death
5
Severe respiratory
insufficiency requiring
continuous O
2
or
ventilation
Life threatening;
Urgent intervention
needed
4
Severe cough
requiring steroids/ O
2
SOB at rest; limiting
self care ADL
3
www.fda.gov/cder/cancer/toxicityframe.htm