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CTV - PTV margin = 2.5 • Σ + 0.7 • σ

Σ: population systematic error

= SD of overall population mean setup error

σ: population random error

= average of SDs of individual daily random error

Margin calculation recipe

van Herk et al. IJROBP 47:1121-1135, 2000

-2,0

-1,5

-1,0

-0,5

0,0

0,5

1,0

1,5

2,0

-2,0

-1,5 -1,0

-0,5

0,0

0,5

1,0

1,5

2,0

mean setup error (systematic)

daily setup error (random

)

Measurements for many patients and many fractions