1241 / 1674
Overall conclusions from the DBCG studies on age effects
BCT patients treated with no adj systemic therapy developed LR throughout a
20-yr period
Among younger BCT patients, 1 patient developed DM for every 2 LR (47
LR:21 DM)
Among older BCT patients LR did not predict later DM (11 LR: 0 DM)
Among older BCT patients molecular subtypes do not predict BCM
Remember: these 2 studies include patients not treated with adj systemic
therapy, so they reflect the natural history.
Today, most of these patients will be offered systemic therapy with the potential
to more than half the risk of recurrence