1393 / 1674
Bentzen SM, Nature reviews Cancer 2006
Orchestrated response to RT
Key processes in radiation
fibrogenesis
TGFβ
is a multifunctional cytokine and
growth factor, strongly profibrotic, involved
in many diseases including cancer.
TGFβ has a dual role in tumour
suppression and promotion.
Another key element is the homeostatic
control of reactive oxygen and nitrogen
species (
ROS and RNS
). It is the
pertubation of the homeostatic control of
ROS and RNS rather than the radical
species themselves that drives the active
biological response to oxidative and
nitrosactive stress.